Pathogenic variants of PRRT2 are associated with a large spectrum of familial neurological disorders: PRRT2 is primarily associated with paroxysmal dyskinesia (PKD) but also hemiplegic migraine (HM), infantile convulsions and choreoathetosis (ICCA) and benign sporadic and familial seizures (BFIS) (84, 85). This evidence concerns the gene PRRT2 and familial or sporadic hemiplegic migraine.