The activation of hypoxia signaling increases the expression of adipokines, especially the pro-inflammation adipokines (including CCL2, CXCL8, CXCL10, IL-18, IL-1α and Oncostatin M), which is involved in the recruitment of tumor-associated immune cells (Taylor and Colgan, 2017; Hou et al., 2020; McGettrick and O’Neill, 2020). The gene discussed is IL1A; the disease is neoplasm.