METTL3 and breast cancer: Furthermore, in breast cancer cells, METTL3 was found to participate in a feedback loop with HBXIP, a co-factor of anti-apoptotic protein SURVIVIN, wherein HBXIP up-regulated METTL3 expression by suppressing METTL3 inhibitor let-7g, an miRNA (Garcia-Saez et al., 2011; Cai et al., 2018).