Shao et al. identified that BNIP3 inactivation in renal cancer was probably caused by histone deacetylation, rather than methylation, and the histone deacetylation inhibitor can restore the expression of BNIP3 in renal cancer, subsequently resulting in growth inhibition and apoptotic promotion (Shao et al., 2019). This evidence concerns the gene BNIP3 and renal carcinoma.