CIP2A and triple-negative breast carcinoma: Chen et al. (2020) observed highly expressed LINC00665 in prostate cancer tissues, and it could significantly promote the expression of SND1 by inhibiting miR-1224-5p through bioinformatics and functional experimental analysis. As a short peptide encoded by LINC00665, CIP2A-BP is also found to have an indispensable role in many cancers. For example, CIP2A-BP can interact with CIP2A to inhibit the PI3K/Akt/NFkB pathway in triple-negative breast cancer, thereby affecting the survival activity of cancer cells (Guo et al., 2020).