Furthermore, it has been reported that there was an increased infiltration of macrophages in torn supraspinatus tendon from human tendinopathy (Millar et al., 2010), and the NF-κB pathway was found to be upregulated in fibrous tissue formed around the tendon in both human and rat samples (Chen et al., 2017). Here, NFKB1 is linked to disease of the tendon.