The specific mechanism is not clear, although it may be possible that the release of various inflammatory mediators induces an increase in platelets, while activated platelets contribute to the release of platelet-derived growth factor, platelet-activating factor, and vascular endothelial growth factor, which accelerate tumor-related blood vessel formation and extracellular matrix degradation, promoting tumor growth and distant metastasis (17). Here, VEGFA is linked to neoplasm.