For instance, adoptive transfer of donor derived CD5+CD1dhi Bregs at the time of allogeneic bone marrow transplantation has been described to significantly reduce the severity of sclerodermatous GvHD [112], and in a murine leukaemia setting co-transfer of CD5+CD1dhi Bregs could significantly reduce the severity of GvHD while importantly maintaining an effective immune response against murine acute myeloid leukaemia cells [113]. This evidence concerns the gene CD5 and graft versus host disease.