Further analysis showed that interferon gamma (IFNγ), a potent inducer of Cxcl10 and Cxcl9, was lower in NK and CD8 T cells in CLL rechallenged mice (Figures 7B and 7C), suggesting that alveolar macrophages may be necessary for optimal activation of this pathway. This evidence concerns the gene CXCL10 and B-cell chronic lymphocytic leukemia.