AICDA and infection: Following primary infection or vaccination, B cells that are specific for virally derived antigens are activated in secondary lymphoid organs (SLOs) where they may subsequently mature the affinity of their antibodies through iterative rounds of activation-induced cytidine deaminase (AID)-catalyzed somatic hypermutation and selection in germinal centers (GCs) (Bannard and Cyster, 2017; Victora and Wilson, 2015).