PLG and Parkinson disease: Interestingly, α‐syn variants with point mutations (A30P, E46K, and A53T) seen in patients with early‐onset familial PD are cleaved by plasmin with equal efficiency compared to WT α‐syn (Kim et al., 2012), and, as explained above, plasmin physiological function may primarily consist in the proteolysis and inhibition of cell‐to‐cell propagation of extracellular α‐syn (Kim et al., 2012).