We observed several genes that contribute to GO:0005515 from chromosomes 1, 2, 8, 11, 16, 18 and 22, including LEPR1, TMEM18, PPP1CB, SPDYA, TRMT61B, MSRA, TRPS1, C11orf49, FTO, PTPN2, LDLRAD4, RNMT, GTPBP1 and SUN2. We also examined genes in colocalization between RA and CRP and found two additional genes that are components of GO:0005515, including HLA-DRB1 and HLA-DQA1. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.