Fisher’s test conducted for the GO molecular functions class using the classic algorithm revealed that GO:0005515 is significantly over-represented in SNPs associated with RA (P = 3.30E−10), CRP (P = 5.90E−07) and several OP traits, including UKB OP (P = 1.40E−15), total BMD (P = 2.40E−14), spine BMD (P = 1.40E−19), hip BMD (P = 1.20E−10) and UKB heel BMD (P = 3.10E−06), annotated over 13 000 genes (Supplementary Material, Table S9). This evidence concerns the gene CRP and rheumatoid arthritis.