Since CD2 ligands were found to be downregulated in the context of AML relapse and CD2 was highly expressed on CD56dim CIML NK cells (Figure 5D), we evaluated the effect of blocking CD2 on CIML NK activation, cytokine secretion, or cytotoxicity in vitro using a blocking anti-CD2 monoclonal antibody. Here, CD2 is linked to acute myeloid leukemia.