It was observed that under HFD conditions, livers from LKO mice showed a significant upregulation of the expression of all genes (Figure 2A), including PPARγ, (encoded by Pparg), a key regulator of lipogenesis that is induced in steatotic livers of patients with NAFLD and experimental models (13, 14). This evidence concerns the gene PPARG and metabolic dysfunction-associated steatotic liver disease.