ACTG1 and colorectal carcinoma: In this study, it was further testified the biological role of the brand-new circRNA PCLE1 in CRC macrophage polarization, glycolysis and EMT, manifesting that circPLCE1 expedited TAM M2 polarization, and CRC EMT and glycolysis via competitively binding miR-485-5p to mediate ACTG1.