INS and diabetes mellitus: Despite all this, the treatment algorithms become complicatedsince diabetes is a disease that progresses, and a loss of pancreaticβ-cell mass occurs, which leads to the need to treat with insulin.Therefore, the satisfactory management of glycemic control has remaineda major clinical challenge in diabetic patients, and the alarminglyincreasing incidence of type 2 diabetes worldwide has promoted theurgent need for novel therapeutic approaches.