GAP43 and epilepsy: Furthermore, our findings suggest that serum GAP-43 can be used as a good negative biomarker for excluding epilepsy in children when combined with clinical correlation, as the results of our study on the characteristic performance of serum GAP-43 in diagnosing epilepsy revealed that GAP-43 was more sensitive than specific at cut-off point ≤ 0.6 ng/mL, with a higher negative predictive value than positive predictive value.