AKT1 and neoplasm: Furthermore, many studies have demonstrated that EGCG can prevent tumor growth and inhibit angiogenesis and tumor metastasis by regulating various signaling pathways, including the p38/MAPK [14], PI3K/Akt [15], and Wnt/β-catenin [16] pathways, which are closely related to cell proliferation, apoptosis, and migration in tumors.