KLK15 and cardiovascular disorder: 2015). It has been reported that decreased ACO2 levels in the heart are associated with cardiovascular diseases (Vivanco et al. 2003). In a plant study, aconitate hydratase (ACO) was reported to have antioxidative stress properties (Moeder et al. 2007). Hence, the effect of sericin, which reduced ACO2 expression, did not recover cardiac mitochondrial dysfunction under hypercholesterolemic conditions. In contrast, when observed in liver mitochondria, ACO2 has been shown to be upregulated by sericin and to maintain antioxidative stress activity (Ampawong et al. 2018).