CD34 and chronic myelogenous leukemia, BCR-ABL1 positive: Consistent with CML cell lines, treatment of BP-CML CD34+ cells with the combination of stachydrine and TKI resulted in remarkable induction of apoptosis, and inhibition of colony formation and self-renewal, whereas only modest induction of apoptosis and reduction in inhibition of colony formation and self-renewal were seen with TKI alone (Figure 4(A–C)).