Several studies reported that decreased FXR expression leads to tumorigenic phenotypes in breast, bile duct, colon, liver, and intestine while there are also studies that support that the overexpression of FXR protein induces non-small cell lung cancer and esophageal cancer and esophageal adenocarcinoma [20,22–28]. The gene discussed is NR1H4; the disease is non-small cell lung carcinoma.