Dysregulation of the NLRP3 signaling has been implicated in a variety of inflammatory, neurodegenerative, and metabolic diseases such as atherosclerosis, Alzheimer's disease, Parkinson's disease, and diabetes.[25, 26] However, whether activation of the NLRP3 inflammasome is involved in surgery‐induced cerebral dysfunction is not known. This evidence concerns the gene NLRP3 and metabolic disease.