CD274 and neoplasm: The findings indicated that the upregulation of PD‐L1 boosted the tumor growth which reflected by increased tumor volume and weight compared with the NC vector group (p < 0.05 or p < 0.01), and the overexpression of exosomal miR‐16‐5p in cell culture medium partially weakened the role of overexpression of PD‐L1 (p < 0.05) (Figure 6C, D).