Furthermore, PD‐L1 expression in tumors (including LUAD) detected by using the immunohistochemistry assay has been considered as an unneglectable step in the standard practice for immunotherapy with antibodies against PD‐1/PD‐L1, and blocking of the mutual action of PD‐1 with PD‐L1 can restrain tumor growth and possibly result in complete remission of cancer.39 This evidence concerns the gene CD274 and cancer.