Jiang et al. successfully synthesized a sequence of hybrid compounds through reacting BB to Benzene-1,2-diol, N-Acetyl-5-Methoxytryptamine, and FA, agent showed potential for AD, was modified as BB-pyrocatechol hybrid (compound 19) appear more efficient in inhibiting AChE than the parent BB (IC50: 0.123 vs 0.374 μM). Here, ACHE is linked to Alzheimer disease.