The aim of this study is to identify miRNAs useful to the differential diagnosis of indeterminate thyroid nodules; specifically, we analyzed nodules with homogeneous cytological diagnosis (TIR3A and TIR3B), absence of point mutations in BRAF and RAS genes and available histological diagnosis of benign and malignant low-risk thyroid lesions, namely follicular adenoma, NIFTP and follicular variant of PTC. The gene discussed is BRAF; the disease is thyroid nodule.