AUC, sensitivity, specificity, LR+ and LR− for serum IL-34, MCSF or AFP for diagnosing HBV-HCC are shown in Fig. 2B. AUC values for serum IL-34, MCSF or AFP were 0.683 (0.605–0.761), 0.635 (0.556–0.714) or 0.810 (0.746–0.874), respectively (Fig. 2). This evidence concerns the gene IL34 and hepatocellular carcinoma.