EGFR and lung carcinoma: Additionally, the International Association of the Study of Lung Cancer (IASLC) consensus statement in 2018 concluded that ctDNA approaches have significant potential to improve patient care, and immediate implementation in the clinic is justified in a number of therapeutic settings in NSCLC including in the diagnosis of EGFR tyrosine kinase inhibitor (TKI) resistance (EGFR T790M) [28].