PPARGC1A and melanoma: As it is beyond the scope of this paper, we publish this paper to demonstrate the potential of PGC1α derived mitochondrial biogenesis in MSCs as a therapeutic target and thus pave way for further research into PGC1α derived mitochondrial biogenesis in MSCs including the impact of PGC1α activity on general activity of MSCs, comparison of transcriptional profiles of activated MSCs and PGC1α KD MSCs, and melanoma-derived factors inducing mitochondrial biogenesis in MSCs.