COL7A1 and recessive dystrophic epidermolysis bullosa: Taken together, these data demonstrate B-VEC-mediated COL7A1 gene delivery, expression, and correct ultrastructural localization of functional, full-length C7 (inclusive of both NC1 and NC2) in RDEB mouse and primary human RDEB skin xenograft models, both of which closely recapitulate the RDEB skin phenotype.