The C-terminus (GIPC) family contains three members (GIPC1, GIPC2, and GIPC3) that contain GIPC homology 1 (GH1), PDZ, and GH2 domains with functional similarity and evolutionary conservation, and GIPCs participate in processes driving familial hearing loss and cancer, such as planar cell polarity, cytokinesis, cell proliferation, and migration [19, 20]. This evidence concerns the gene GIPC2 and cancer.