Furthermore, GIPC2 is an endocrine-specific conditional tumor suppressor, whose inactivation is associated with promoter hypermethylation in sporadic and hereditary pheochromocytoma/paraganglioma (PPGL) via inactivation of p27 and suppression of PPGL cell proliferation and tumor growth both in vitro and in vivo [28]. The gene discussed is GIPC2; the disease is neoplasm.