KLK3 and Familial prostate cancer: The aim was further to apply the method to evaluate the effect of a diet high in whole grain/bran rye-based foods rich in BXs vs fiber supplemented refined wheat on the structural and quantitative variety of BXs and BX-derived metabolites in plasma samples after regular consumption, and to investigate whether the concentrations of any of such metabolites correlated with PSA levels in men with indolent prostate cancer.