Such alterations include fusions, like RUNX1-RUNX1T1 and CBFB-MYH11; KMT2A rearrangements; NUP98 rearrangements; and sequence mutations, like FLT3, KIT, WT1, CEBPA, and NPM1, which are among the most commonly mutated genes in pediatric AML. This evidence concerns the gene RUNX1 and acute myeloid leukemia.