RUNX1T1 and acute myeloid leukemia: Such alterations include fusions, like RUNX1-RUNX1T1 and CBFB-MYH11; KMT2A rearrangements; NUP98 rearrangements; and sequence mutations, like FLT3, KIT, WT1, CEBPA, and NPM1, which are among the most commonly mutated genes in pediatric AML.