Strikingly, although we observed no significant genotypic effect on asthma risk in T2-high subjects, we found a strong additive effect of rs8103278 genotype on asthma risk in T2-low subjects (asthma OR (additive genotypic model) = 1.71, p = 5.2E–3), suggesting that the effect of FOXA3 expression on asthma risk may only occur up to a certain threshold of expression, which is commonly exceeded in T2-high subjects. This evidence concerns the gene FOXA3 and asthma.