NESTIN, which has been proposed as a possible diagnostic biomarker for diagnosing combined hepatocellular carcinoma-intrahepatic cholangiocarcinoma (cHCC-ICC)15, was mostly expressed in S100P- iCCA cases, suggesting the possible similarities between cHCC-ICC and S100P- iCCA. The gene discussed is S100P; the disease is intrahepatic cholangiocarcinoma.