DBH and hypertensive disorder: In FinnGen, the DBH p.Arg79Trp vanillylmandelate-decreasing allele was significantly associated with lower hypertension risk (OR = 0.84, P = 5.2 × 10−13), consistent with previous associations with systolic and diastolic blood pressures53,54. No other variants were associated with FinnGen hypertension or METSIM vanillylmandelate in this region (P > 10−6; Supplementary Fig. 11).