Our group has shown that the expression of SelS is increased in the white adipose tissue (WAT) of obese subjects and high-fat diet (HFD)-fed mice, while knockdown of SelS induces 3T3-L1 preadipocyte differentiation defect, indicating that SelS is involved in the pathogenesis of obesity [11]. Here, SELENOS is linked to obesity due to melanocortin 4 receptor deficiency.