To address this and ascertain whether the cGAS and STING signals were coming from H1975 cells and macrophages respectively, we co-stained with F4/80 and observed that the increase in perinuclear STING was exclusively restricted to macrophages, particularly after the combination osimertinib/anti-HER3 (Fig. 5A–C and S6A–C), suggesting that macrophage STING could be activated because of tumor-cell cGAS activation post-osimertinib. Here, ERBB3 is linked to neoplasm.