Also, the Masson staining demonstrated induction of myocardial fibrosis by METTL3 over-expression in MA treated TAC mice (Figure 4I), which was evident by the elevated mRNA (Figure 4J) and protein (Figure 4K) expression of Fibronectin, Collagen I, and α-SMA. The gene discussed is ACTA1; the disease is Myocardial fibrosis.