Moreover, ITGB5 served as a ligand for Cyr61, a molecule stimulating the production of IL-6, which is considered an aging biomarker, via itgav/itgb5/Akt/NF-κB signaling pathway in RA [63, 64], further supporting its role in various mechanisms underlying multiple AADs. The gene discussed is NFKB1; the disease is rheumatoid arthritis.