We initially confirmed that PABPC1 and IFI27 could mediate the expression of miR-21-5p in ESCC cells (Fig. 6E), and then we extracted exosomes from ESCC cells transfected with Cy3-labeled miR-21-5p mimics, and added the exosomes to HUVECs. The gene discussed is PABPC1; the disease is esophageal squamous cell carcinoma.