The clinical significance of PABPC1 in ESCC was analyzed in samples from our own cohort and a public database (TCGA), which showed PABPC1 is upregulated in ESCC tissues compared with in case-matched normal epithelial tissues, which is consistent with several previous reports focusing on prostate cancer, HCC, and gastric cancer [24]. This evidence concerns the gene PABPC1 and Familial prostate cancer.