IFI27 expression was significantly higher in ESCC tissues compared to paired non-tumor tissues in the GSE20347 (n = 34) and GSE23400 cohorts (n = 106), as well as in our ESCC cohort detected by western blotting (n = 24) and immunohistochemistry (n = 190) (Figure S5B-D). The gene discussed is IFI27; the disease is esophageal squamous cell carcinoma.