Taken together, the comprehensive analysis of TME in this study informs the design of clinical trials including a recently initiated clinical trial of testing durvalumab anti-PD-L1 antibody in combination with a CSF-1R inhibitor (SNDX-6532) following chemo or radio-embolization for patients with intrahepatic cholangiocarcinoma (NCT04301778). The gene discussed is CSF1R; the disease is intrahepatic cholangiocarcinoma.