Thus, it is conceivable that CD3+CD8+EOMES−PD-1− T cells that infiltrate within the tumor areas may play a stronger role in antitumor immune response in ICC than those in the peripheries of the tumors or that a stronger antitumor immune response would be elicited only when this non-exhausted subtype of CD8+ T cells have infiltrated into the tumor areas. The gene discussed is CD8A; the disease is neoplasm.