In ICC, combining Treg with either PD-L1+ M1 TAM or PD-L1+ M2 TAM (Fig. 5S, V), respectively, as immune parameters identifies one subgroup of ICC with approximately 90% being long-term survivors and another subgroup with more than 90% having a dismal prognosis (Fig. 5U, X). This evidence concerns the gene CD274 and intrahepatic cholangiocarcinoma.