We also found that the densities of NK cells, Th2 cells, CD8+Granzyme B+ T cells, and CD3+CD8+EOMES−PD-1− T cells, respectively, were significantly decreased in the peripheries compared to the tumor areas in ICC, but not DCC (Additional file 1: Figs. S5, S6). The gene discussed is GZMB; the disease is neoplasm.