In ICC, EOMES+CD8+ T cells do appear to distribute similarly as LAG3+ or TIM3+ CD8+ T cells particularly in the tumors with possibly a more immunosuppressive TME according to the single cell RNA sequencing analysis (below Additional file 1: Fig. S17), suggesting that EOMES is a T cell exhaustion marker as LAG3 and TIM3 in ICC. The gene discussed is LAG3; the disease is intrahepatic cholangiocarcinoma.