Here, similar to DCC, high density of PD-L1− M2 TAM is also associated with a good prognosis albeit in a subgroup of ICC; however, different from DCC, high density of PD-L1− M2 TAM or high density of PD-L1− M1 TAM, not necessarily both together, is associated with a good prognosis in ICC. Here, CD274 is linked to intrahepatic cholangiocarcinoma.