In particular, the intrinsic properties of these two IgG1 mAbs could render suitable their combination, whose anti-cancer mechanism of action is, in part, dependent on innate immunity, including NK cell-driven ADCC and STING pathway activation, as a rechallenge strategy in NSCLC patients with DDR somatic and/or germline mutations. Here, STING1 is linked to non-small cell lung carcinoma.