We have recently conducted a proof-of-concept study in pre-treated NSCLC patients with the combination of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) cetuximab and the anti-PD-L1 mAb avelumab (the Cetuximab-AVElumab-Lung, CAVE-Lung trial) [5]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.