In addition, mutant myocilin proteins interact with components of the extracellular matrix (ECM), including fibronectin, elastin, and collagen type IV and I, resulting in aberrant accumulation of ECM proteins in the ER and dysregulation of the ECM, which contributes to reduced outflow of aqueous humor and increased IOP in some glaucoma cases [144]. The gene discussed is MYOC; the disease is glaucoma.