VEGFA and wet macular degeneration: Current standard treatment options include intravitreal anti-vascular endothelial growth factor (VEGF) therapies for MNV in patients with wet AMD or nAMD, which significantly reduce vascular leakage in most cases, and inhibit vascular growth in some; however, its overall long-term effect on MNV regression or inhibition of MNV expansion remains suboptimal [43, 46].