Jia et al. discovered that knockdown of TUG1 alleviated blood-spinal cord barrier leakage and improved hind-limb motor function by upregulating miR-29b-1-5p and suppressing metadherin (MTDH)/NF-κB pathway-mediated inflammatory cytokines expression after spinal cord ischemia-reperfusion [133]. Here, MTDH is linked to spinal cord ischemia.