For example, it was described that miR-429 exhibited lower expression in glioma endothelial cells (GECs), an in vitro BTB model, and overexpression of miR-429 in GECs significantly decreased the expression of tight junction proteins ZO-1, occludin, and claudin-5, as ZO-1 and occludin were direct targets of miR-429 [146]. This evidence concerns the gene OCLN and central nervous system cancer.