MMP2 and tuberous sclerosis: In tuberous sclerosis complex (TSC), high protein expression of MMPs (MMP2, 3, 9, and 14) and TIMPs (endogenous tissue inhibitors 1, 2, 3, and 4) in TSC tubers was associated with BBB dysfunction, while these dysregulated proteins can be partly rescued by miR-146a and miR-147b in tuber-derived TSC cultures [204].