Moreover, in breast cancer brain metastasis, Pan et al. demonstrated that high levels of miR-211 drove early and specific brain colonization of tumor cells to enhance their stemness properties and trans-BBB adherence and migration to promote brain metastasis by downregulating the SOX11 (SRY-Box Transcription Factor 11)/NGN2 (neurogenin 2)-dependent axis in vivo [152]. The gene discussed is NEUROG2; the disease is breast cancer.