Moreover, Lnc-BM enhances the STAT3 (signal transducer and activator of transcription 3)-dependent expression of ICAM1 and CCL2 (C-C chemokine ligand 2, monocyte chemoattractant protein-1, MCP-1), which mediated vascular invasion and recruitment of macrophages in the brain, respectively, to increase the cancer cell migration through BBB and to exacerbate BCBM [62]. Here, STAT3 is linked to cancer.