For example, Zhang et al. reported that miR-96 could target erythroblast transformation-specific (ETS) transcription factor ERG (ETS-related gene) to inhibit ERG protein expression, which can bind to ZO-1 promoter region to downregulate the ZO-1 transcription in BMECs; thus, inhibition of miR-96 prevented ZO-1 downregulation induced by GM-CSF (granulocyte-macrophage colony-stimulating factor) in AD environments [179]. This evidence concerns the gene CSF2 and Alzheimer disease.