Moreover, one group found that in colorectal cancer, Ovol2 directly binds with Tcf4 and β-Catenin through protein–protein interactions to inhibit Wnt signaling and EMT [22], and our recent study showed that poly(ADP-ribosyl)ated Ovol2 plays an important role in regulating the chromosomal aneuploidy and death of cancer cells [23]. The gene discussed is OVOL2; the disease is colorectal cancer.