Several strategies are worth pursuing in targeting cancers dependent on FBXW7 loss of function(s): 1- targeting the reactivation of FBXW7 expression in the case of tumors with wild type FBXW7 that is inactivated through epigenetic mechanisms, or 2-targeting downstream effectors of FBXW7 inactivation in case of gene mutation or deletion. Here, FBXW7 is linked to cancer.