Compared to the non-neoplastic and adenoma polyp subgroups, circulating Fib and FPR were significantly higher in the CRC subgroup (all p < 0.01), conversely, Alb, pAlb, and AFR were low in early-stage CRC patients compared to colorectal benign polyps cases in the two cohorts (all p < 0.01). The gene discussed is FBL; the disease is colorectal carcinoma.