In discriminating CRC from benign colorectal polyps, the AUCs, Sen, and Spe were 0.792, 65.10%, and 81.30%, for FPR, respectively, and 0.754, 75.50%, and 33.10% for AFR, respectively, and their AUCs were superior to CEA and CA19-9, respectively (Fig. 3A, Table 2). The gene discussed is CEACAM5; the disease is colorectal carcinoma.