These 10 potential key genes (EIF1AY, RPS4Y1, USP9Y, KDM5D, DDX3Y, NPPA, HBB, TSIX, LOC28556, XIST) and some important pathways related to the risk of heart failure have been identified, indicating that these may play an important role in the mechanism of the occurrence and development of heart failure. Here, RPS4Y1 is linked to heart failure.