However, the MSIS criteria would probably lead to diagnosis or misdiagnosis in the first step of evaluating serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) which have limited value for screening and diagnosing PJI due to their unsatisfying sensitivity and reliability, when facing a considerable number of patients infected by slow-growing organisms, in early postoperative periods, or with a low level of inflammation and subtle clinical symptoms [6–9]. The gene discussed is CRP; the disease is juvenile polyposis syndrome.