Consequently, the present study aimed to determine whether ZIP12 is implicated in the regulation of the proliferation and migration of PASMCs, and to assess the role of ZIP12 in the PI3K/AKT and ERK signaling cascades in PASMCs, which can enhance our understanding of the pathophysiological role of ZIP12 in PAH. Here, AKT1 is linked to pulmonary arterial hypertension.