However, the risk of grade 1–5 diarrhea and rash significantly increased in adjuvant EGFR-TKIs group (Diarrhea: RR 3.17, 95% CI 2.71–3.71; Rash: RR 4.12, 95% CI 3.51–4.84). Here, EGFR is linked to Diarrhea.