EGFR and non-small cell lung carcinoma: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as erlotinib [10], gefitinib [11] and osimertinib [12] are the recommended first-line treatments for advanced NSCLC harboring driver gene mutations (such as small multi-nucleotide in-frame deletions in exon 19 and a point mutation in exon 21 resulting in substitution of leucine for arginine at position 858 (L858R) of EGFR) [13, 14].