EGFR and Diarrhea: However, the pooled RRs of grade 3–5 diarrhea and rash incidence were significant for the adjuvant EGFR-TKIs group (Diarrhea: RR 5.68, 95% CI 2.94–10.98; Rash: RR 27.74, 95% CI 11.43–67.30).